Semaglutide is a medication that has been approved by the US Food and Drug Administration (FDA) for treating type 2 diabetes. However, recent clinical trials have shown that semaglutide is also effective for weight loss. In this article, we will explore the effectiveness of semaglutide for weight loss based on the results of these clinical trials.
Introduction
Semaglutide is a medication that belongs to the class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. It works by increasing insulin secretion and decreasing glucagon secretion, which helps to lower blood sugar levels in people with type 2 diabetes.
Clinical Trials on Semaglutide for Weight Loss
Several clinical trials have been conducted to investigate the effectiveness of semaglutide for weight loss. In one study, researchers recruited 1,961 adults with obesity or overweight and no diabetes. The participants were randomly assigned to receive either a weekly injection of semaglutide or a placebo injection for 68 weeks.
Study Design
The study was a randomized, double-blind, placebo-controlled trial. Participants received either 2.4 mg of semaglutide or placebo, administered subcutaneously once weekly for 68 weeks. All participants received lifestyle counseling.
Results
After 68 weeks, participants who received semaglutide had an average weight loss of 14.9%, while those who received the placebo had an average weight loss of 2.4%. Additionally, a greater proportion of participants who received semaglutide achieved a weight loss of 5% or more (86.4%) compared to those who received the placebo (31.5%).
Side Effects
The most common side effects of semaglutide were nausea, diarrhea, vomiting, and constipation. These side effects were generally mild to moderate in severity and tended to diminish over time.
How Does Semaglutide Work for Weight Loss?
The exact mechanism by which semaglutide promotes weight loss is not yet fully understood. However, it is thought to work by reducing appetite and increasing feelings of fullness.
Semaglutide stimulates the GLP-1 receptors in the brain, which regulate appetite and food intake. By activating these receptors, semaglutide can reduce hunger and increase satiety, leading to a decrease in calorie intake and subsequent weight loss.
Who Can Benefit from Semaglutide for Weight Loss?
Semaglutide is not intended for use in people without obesity or overweight. It is currently approved for use in adults with a body mass index (BMI) of 27 kg/m2 or greater who also have at least one weight-related condition, such as hypertension, type 2 diabetes, or dyslipidemia.
Conclusion
Clinical trials have shown that semaglutide is effective for weight loss in adults with obesity or overweight. The medication works by reducing appetite and increasing feelings of fullness, leading to a decrease in calorie intake and subsequent weight loss. Semaglutide is not intended for use in people without obesity or overweight.
Ready to kickstart your weight loss journey?
Contact Concord Wellness and we’ll evaluate if our semaglutide program is right for you. If eligible, book your first appointment with our doctors for an initial assessment. Call San Diego (619) 905-4247 or Los Angeles (818) 800-2002 to schedule a consultation today! Don’t wait to prioritize your health with Concord Wellness.